Prevalence and seasonal variation of human intestinal parasites in patients attending hospital with abdominal symptoms in northern Jordan.

This study was carried out to determine the prevalence of intestinal parasites and their seasonal variation in northern Jordan. A total of 21 906 stool samples were collected over a period of 4 years (2009- 2013) from 5 government hospitals in 3 cities. Samples were processed and examined microscopically and by concentration methods. Parasitic infection was found in 9611 samples (44%). Giardia lamblia was the most prevalent parasite (41%) followed by Entamoeba histolytica (31%) and Ent. coli (13%); the least prevalent parasites were Ascaris lumbricoides (1%), Hymenolepis nana, Taenia sp., and Chilomastix mesnili (all < 1%). The prevalence of different parasites varied according to season, on average the summer months showed the highest incidence of parasitic infection (62%) compared with the winter months (16%). Giardia lamblia and Ent. histolytica were most prevalent in the summer months.

Prevalence and seasonal variation of human intestinal parasites in patients attending hospital with abdominal symptoms in northern Jordan

This study was carried out to determine the prevalence of intestinal parasites and their seasonal variation in northern Jordan. A total of 21 906 stool samples were collected over a period of 4 years [2009-2013] from 5 government hospitals in 3 cities. Samples were processed and examined microscopically and by concentration methods. Parasitic infection was found in 9611 samples [44%]. Giardia lamblia was the most prevalent parasite [41%] followed by Entamoeba histolytica [31%] and Ent. coli [13%]; the least prevalent parasites were Ascaris lumbricoides [1%], Hymenolepis nana, Taenia sp., and Chilomastix mesnili [all < 1%]. The prevalence of different parasites varied according to season, on average the summer months showed the highest incidence of parasitic infection [62%] compared with the winter months [16%]. Giardia lamblia and Ent. histolytica were most prevalent in the summer months

La présente étude a été menée afin de déterminer la prévalence de parasites intestinaux ainsi que leur variation saisonnière dans le nord de la Jordanie. Un total de 21 906 échantillons de selles ont été collectés sur une période de 4 ans [2009-2013] dans cinq hôpitaux gouvernementaux de trois villes. Les échantillons ont été traités et examinés à la microscopie et à l'aide de méthodes de concentration. Une infection parasitaire a été trouvée dans 9611 échantillons [44%]. Giardia lamblia était le parasite avec la prévalence la plus élevée [41%], suivi par Entamoeba histolytica [31%] et Entamoeba coli [13%]. Les parasites ayant la plus faible prévalence étaient Ascaris lumbricoides [1%], Hymenolepis nana, Taenia sp., et Chilomastix mesnili [tous < 1%]. La prévalence des différents parasites variait en fonction de la saison: en moyenne, les mois d'été affichaient la plus haute incidence d'infections parasitaires [62%] comparés aux mois d'hiver [16%]. Giardia lamblia et Ent. histolytica étaient les plus prévalents au cours des mois d'été

Antibiotic accumulation and membrane trafficking in cystic fibrosis cells.

Cystic fibrosis (CF) results from mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) which is a regulated chloride channel. The deltaF508 mutation prevents the post-translational glycosylation and membrane insertion of the protein. Severe disease follows, with the formation of a viscous mucus and subsequent chronic bacterial infection of the lungs, necessitating frequent, and often long, periods of antibiotic treatment. The pharmacokinetics of antibiotics in CF patients are abnormal, with lower blood serum levels and higher clearance rates which have never been satisfactorily explained. We found that accumulation of gentamicin in nasal polyp tissue non-CF cells was subject to regulation by the effectors and inhibitors of CFTR function; regulation was lost in deltaF508 CF cells and accumulation was more than doubled because of the inhibition of exocytosis.